MODELS OF CHRONIC PANCREATITIS

Animal Models of Chronic Pancreatitis

Chronic pancreatitis is a progressive, inflammatory disease of the pancreas, which leads to inflammation and fibrosis, with the potential for exocrine and endocrine insufficiency. The prevalence of the disease is estimated to be 42 per 100,000 and rising (40,105). The pathogenesis of chronic pancreatitis is incompletely understood and complex, involving the interplay of environmental, metabolic...

Animal Models of Chronic Pancreatitis

Animal models for CP in rats can be classified into 2 groups: one is noninvasive or nonsurgical models and the other is invasive or surgical models. Pancreatic injury induced by repetitive injections of supramaximal stimulatory dose of caerulein (Cn) or by intraductal infusion of sodium taurocholate (NaTc) recovered within 14 days, whereas that caused by repetitive injection of arginine or by i...

Animal Models of Acute and Chronic Pancreatitis

Animal models for investigating chronic pancreatitis

Chronic pancreatitis is defined as a continuous or recurrent inflammatory disease of the pancreas characterized by progressive and irreversible morphological changes. It typically causes pain and permanent impairment of pancreatic function. In chronic pancreatitis areas of focal necrosis are followed by perilobular and intralobular fibrosis of the parenchyma, by stone formation in the pancreati...

pancreatitis, and chronic pancreatitis

EDITORIAL SYNOPSIS Two hundred and five confirmed cases of pancreatitis have been classified. Primary calcifying pancreatitis is associated with alcoholism. Pancreatic changes are patchy and related to plugging of minute ducts. Cysts are frequent. Obstruction to the main pancreatic duct may also result in chronic pancreatitis. Acute pancreatitis and acute recurrent pancreatitis are often associ...